Table 4. VEGAS Pathway Analysis results from gene-based meta-analysis.
| GO ID | GO Term | P value* | Genes |
|---|---|---|---|
| GO:0035282 |
Segmentation |
2.0×10−6 (0.009) |
PSEN2, WNT3A, MSGN1, TCF7L1, ZEB2, HOXD8, TDGF1, RBPJ, LEF1, SFRP2, TBX18, DLL1, MEOX2, HOXA2, NKX3–1, SFRP1, PRKDC, MLLT3, ROR2, BMI1, EGR2, ATM, FRS2, MYF5, TBX3, PCDH8, PSEN1, MESP2, RPGRIP1L, ACD, DVL2, HES7, TCAP, KAT2A, MEOX1, HOXB6, AXIN2, MIB1, DLL3, TCF15, PAX1, POFUT1, MAFB, EP300 |
| GO:0009880 |
Embryonic pattern specification |
4.8×10−5 (0.222) |
DISP1, MSGN1, TCF7L1, HOXD8, SATB2, CTNNB1, TDGF1, CXXC4, SMAD1, FGF10, SMAD5, DLL1, MEOX2, HOXA2, MLLT3, BMI1, NODAL, FRAT1, ZBTB16, FRS2, TBX3, SMAD6, RPGRIP1L, DVL2, LHX1, MEOX1, HOXB6, SMAD2, MAFB, BMP7, SIM2 |
| GO:0007379 | Segment specification | 1.4×10−4 (0.648) | MSGN1, DLL1, MEOX2, HOXA2, MLLT3, BMI1, RPGRIP1L, DVL2, MEOX1, MAFB |
Biologic pathways implicated with development of corneal astigmatism.* p values displayed first as uncorrected for number of pathways tested, with value after Bonferroni correction in parenthesis.