Table 5. Results of meta-analysis of the association between rs2010963 polymorphism of VEGF-A gene and AMD risk.
| Genotype contrast |
Na |
Cases/ Controls |
OR (95% CI) |
Significance (Z test)b |
Heterogeneity (Q test) |
|||
|---|---|---|---|---|---|---|---|---|
| Z | P | Q | I2 (%) | P | ||||
|
overall |
3 |
614/454 |
||||||
| C versus G |
0.93 (0.77–1.12) |
0.7 |
0.48 |
1.77 |
0 |
0.41 |
||
| CC versus GG |
0.86 (0.56–1.32) |
0.69 |
0.49 |
3.83 |
47.8 |
0.14 |
||
| GC versus GG |
0.88 (0.66–1.17) |
0.87 |
0.38 |
1.28 |
0 |
0.52 |
||
| GC versus CC |
1.02 (0.49–2.15) |
0.07 |
0.94 |
6.07 |
67.1 |
0.04 |
||
| (GC+CC) versus GG |
0.90 (0.68–1.18) |
0.72 |
0.47 |
1.14 |
0 |
0.56 |
||
| CC versus (GG+CG) |
0.96 (0.49–1.89) |
0.1 |
0.91 |
5.48 |
63.5 |
0.06 |
||
| (GG+CC) versus GC |
1.05 (0.81–1.35) |
0.38 |
0.7 |
3.28 |
39.1 |
0.19 |
||
|
wet AMD |
3 |
422/454 |
||||||
| C versus G |
0.90 (0.73–1.11) |
0.94 |
0.34 |
0.09 |
0 |
0.95 |
||
| CC versus GG |
0.81 (0.49–1.32) |
0.83 |
0.4 |
0.71 |
0 |
0.69 |
||
| GC versus GG |
0.85 (0.62–1.17) |
0.98 |
0.32 |
1.42 |
0 |
0.49 |
||
| GC versus CC |
0.95 (0.61–1.48) |
0.22 |
0.82 |
3.7 |
46 |
0.15 |
||
| (GC+CC) versus GG |
0.85 (0.63–1.16) |
0.99 |
0.32 |
0.56 |
0 |
0.75 |
||
| CC versus (GG+CG) |
0.88 (0.58–1.35) |
0.54 |
0.58 |
2.68 |
25.4 |
0.26 |
||
| (GG+CC) versus GC | 1.08 (0.81–1.43) | 0.56 | 0.57 | 3.7 | 46 | 0.15 | ||
aNumber of studies. bRandom-effects model was used when P value for heterogeneity test p<0.1 or I2>50%; otherwise, fixed-effects model was used.