Table 6. Results of meta-analysis of the association between rs3025039 polymorphism of VEGF-A gene and AMD risk.
| Genotype contrast |
Na |
Cases/ Controls |
OR (95% CI) |
Significance (Z test)b |
Heterogeneity (Q test) |
|||
|---|---|---|---|---|---|---|---|---|
| Z | P | Q | I2 (%) | P | ||||
|
overall |
3 |
575/568 |
||||||
| T versus C |
1.12 (0.74–1.70) |
0.56 |
0.57 |
6.66 |
70 |
0.03 |
||
| TT versus CC |
1.60 (0.85–3.03) |
1.46 |
0.14 |
2.68 |
25.3 |
0.26 |
||
| CT versus CC |
1.01 (0.63–1.59) |
0.04 |
0.96 |
5.49 |
63.6 |
0.06 |
||
| CT versus TT |
1.66 (0.84–3.28) |
1.47 |
0.14 |
0.96 |
0 |
0.61 |
||
| (CT+TT) versus CC |
1.07 (0.67–1.71) |
0.31 |
0.75 |
6.3 |
68.2 |
0.04 |
||
| TT versus (CC+CT) |
1.62 (0.86–3.05) |
1.5 |
0.13 |
2 |
0 |
0.36 |
||
| (CC+TT) versus CT | 1.01 (0.66–1.55) | 0.07 | 0.94 | 4.88 | 59 | 0.08 | ||
aNumber of studies. bRandom-effects model was used when P value for heterogeneity test p<0.1 or I2>50%; otherwise, fixed-effects model was used.