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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Int J Cancer. 2013 Mar 9;133(4):961–971. doi: 10.1002/ijc.28092

Table 3. Association of PhIP-DNA Adduct Levels with Prostate Cancer, Stratified by Matching Factors and Case Characteristics.

Sample
 PhIP Level		 Whole Sample African Americans Whites
ORa 95% CI P value OR 95% CI P value OR 95% CI P value
Low Tumor Grade (n=367 case-control pairs) (n = 137 case-control pairs) (n = 230 case-control pairs)
 2nd Quartile 1.40 0.84-2.31 0.19 1.94 0.83-4.55 0.13 1.17 0.62-2.19 0.63
 3rd Quartile 1.37 0.81-2.33 0.25 1.42 0.53-3.85 0.49 1.30 0.69-2.46 0.41
 4th Quartile 1.29 0.65-2.54 0.47 1.09 0.30-4.01 0.90 1.36 0.61-3.04 0.46
Trend Test 0.51 0.98 0.43
High Tumor Grade (n= 138 case-control pairs) (n = 56 case-control pairs) (n = 82 case-control pairs)
 2nd Quartile 0.92 0.45-1.86 0.81 1.14 0.38-3.44 0.82 0.87 0.33-2.28 0.77
 3rd Quartile 1.57 0.68-3.65 0.29 0.94 0.22-4.08 0.93 2.04 0.69-6.07 0.20
 4th Quartile 1.03 0.31-3.39 0.97 0.45 0.07-2.96 0.41 1.84 0.34-10.00 0.48
Trend Test 0.76 0.43 0.33
1-4 years of Follow-up (n= 266 case-control pairs) (n = 103 case-control pairs) (n = 163 case-control pairs)
 2nd Quartile 1.63 0.91-2.92 0.10 1.83 0.76-4.44 0.18 1.48 0.68-3.24 0.32
 3rd Quartile 1.46 0.75-2.84 0.27 0.99 0.31-3.16 0.99 1.68 0.74-3.84 0.22
 4th Quartile 1.15 0.49-2.69 0.74 0.95 0.23-4.02 0.95 1.23 0.42-3.55 0.71
Trend Test 0.82 0.75 0.67
4-15 years of follow-up (n= 267 case-control pairs) (n = 110 case-control pairs) (n = 157 case-control pairs)
 2nd Quartile 0.90 0.51-1.58 0.72 0.82 0.32-2.11 0.67 0.99 0.48-2.05 0.99
 3rd Quartile 1.34 0.75-2.37 0.32 0.90 0.32-2.55 0.84 1.60 0.78-3.27 0.20
 4th Quartile 1.46 0.70-3.03 0.31 0.62 0.17-2.18 0.45 2.74 1.01-7.42 0.05
Trend Test 0.21 0.53 0.03
Early Cohort entry (n = 263 case-control pairs) (n = 88 case-control pairs) (n = 175 case-control pairs)
 2nd Quartile 1.28 0.69-2.40 0.44 2.46 0.69-8.76 0.17 1.02 0.49-2.12 0.96
 3rd Quartile 1.28 0.68-2.40 0.44 1.92 0.56-6.53 0.30 1.09 0.52-2.29 0.83
 4th Quartile 1.73 0.78-3.86 0.18 2.76 0.60-12.75 0.19 1.42 0.54-3.72 0.48
Trend Test 0.21 0.27 0.47
Late Cohort entry (n=270 case-control pairs) (n = 125 case-control pairs) (n = 145 case-control pairs)
 2nd Quartile 1.10 0.67-1.84 0.69 1.00 0.48-2.10 1.00 1.14 0.55-2.36 0.72
 3rd Quartile 1.40 0.76-2.57 0.28 0.60 0.20-1.77 0.35 2.18 0.99-4.78 0.05
 4th Quartile 0.98 0.46-2.13 0.97 0.29 0.08-1.08 0.06 2.14 0.73-6.24 0.16
Trend Test 0.89 0.06 0.09
Age <65 (n=274 case-control pairs) (n = 110 case-control pairs) (n = 164 case-control pairs)
 2nd Quartile 1.30 0.72-2.35 0.39 0.92 0.38-2.24 0.85 1.79 0.79-4.09 0.16
 3rd Quartile 1.35 0.72-2.53 0.35 0.95 0.35-2.60 0.92 1.71 0.74-3.95 0.21
 4th Quartile 1.08 0.47-2.47 0.85 0.38 0.10-1.42 0.15 2.80 0.87-8.97 0.08
Trend Test 0.83 0.18 0.09
Age 65+ (n=259 case-control pairs) (n = 103 case-control pairs) (n = 156 case-control pairs)
 2nd Quartile 1.10 0.64-1.89 0.72 1.71 0.65-4.50 0.27 0.82 0.41-1.62 0.56
 3rd Quartile 1.45 0.79-2.67 0.23 1.02 0.29-3.60 0.97 1.55 0.76-3.16 0.22
 4th Quartile 1.54 0.72-3.29 0.26 1.52 0.33-7.03 0.59 1.46 0.57-3.45 0.47
Trend Test 0.23 0.78 0.28
a

all risk estimates use lowest quartile as referent group