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. 2013 Jun 6;9(6):e1003394. doi: 10.1371/journal.ppat.1003394

Figure 3. Expression of active NADase plays a central role in the intracellular survival of GAS in oropharyngeal keratinocytes.

Figure 3

A. Intracellular survival of GAS strains 188, 188NADase-, and 188NADase(G330D). Deletion of the gene encoding NADase or inactivation of NADase by the amino acid substitution G330D resulted in a 20- to 40-fold reduction in intracellular survival compared to parent strain 188. *, P<0.001. NADase western blot (B) and activity measurements (C) of culture supernatants from GAS strains 188, 188NADase-, and 188NADase(G330D).