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. 2013 Jun 6;9(6):e1003406. doi: 10.1371/journal.ppat.1003406

Figure 1. Contraction of lineage negative cell and Sca-1 upregulation in malaria are dependent on IFN-γ signaling.

Figure 1

A. Reduction of LIN− and c-Kit (CD117) positive cells in the BM during infection of C57BL/6 mice with P. chabaudi. Significant contraction of absolute numbers was recorded at day 4 and day 7 after infection for LIN− cells and at day 7 for c-Kit+ cells. Ifngr1-null mice did not undergo any significant loss of LIN− or c-Kit+ BM cells during acute malaria. Data represent mean ± SEM of cell number per femur/pair obtained from 15 infection experiments (C57BL/6) or four experiments (Ifngr1-null mice) each with 4–5 mice per group (*:P≤0.05; **: P≤0.01, Mann-Whitney U-test). B. LIN− BM cells from uninfected controls and malaria-infected animals at day 7 of infection with P. chabaudi were co-stained with c-Kit and Sca-1. Of note is the lack of Sca-1 upregulation on Ifngr1­null cells during acute malaria. Data are representative for 19 infection experiments (C57BL/6) or four experiments (Ifngr1-null mice) each with numbers in individual plots indicating the frequency (in %) of the respective population.