Figure 2.

Schematic Drawing of BICD2 and Its Interaction Partners

The diagram depicts a simplified structure of human BICD2. Indicated are the five coiled-coil domains, which are typically combined as coiled-coil domains 1–3. Numbers indicate the respective amino acid residues. In the upper part of the diagram, known interaction partners of the respective coiled-coil domains are given. Please note that the interaction with FMRP is RNA mediated and the interaction between clathrin heavy chain (CLHC) and BICD2 has only been shown for Drosophila so far. In the lower part of the diagram, the four identified variants and a multispecies alignment of the affected amino acids are given. Protein sequences were aligned with blastp.