Figure 6.

Selected Haplotype Forms at EDAR in East Asians

HaploPS-identified haplotype forms that correspond to the identification of a signal of positive selection at EDAR (green horizontal bar). In all four East Asian populations we surveyed, uncharacteristically long haplotypes were found to span EDAR, and these long haplotypes were observed at frequencies of 70% (JPT) and 90% (CHB, CHD, and CHS). These long haplotypes are exactly identical across the common sites, suggesting that any advantageous mutation that is responsible for the presence of the long haplotypes is likely to have arisen in the same mutation event prior to the time of the most recent common ancestor (TMRCA) of these populations. This will thus explain the occurrence of the beneficial allele against an identical haplotype background in the four populations.