Figure 8.

Selected Haplotype Forms at Two Skin-Pigmentation Gene Loci

Haplotypes identified by haploPS to carry the selected alleles at two pigmentation genes, KITLG (A) and SLC24A5 (B) (green horizontal bars).

(A) The KITLG locus has been consistently identified in non-African populations to be positively selected, and the genomic region that is common across all the haploPS haplotypes is perfectly identical, suggesting that the selection sweep most likely happened prior to the TMRCA of these populations.

(B) Similarly, the selected haplotypes at SLC24A5 for Europeans (CEU and TSI) and Gujarati Indians (GIH) are perfectly identical, suggesting that the gene flow between Gujarati Indians and Europeans partly accounts for the lighter skin pigmentation seen across these populations.