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. 2013 Jun 6;92(6):955–964. doi: 10.1016/j.ajhg.2013.04.013

Figure 4.

Figure 4

The p.Ser107Leu Substitution in the Dynein Binding Domain Induces BICD2 Accumulation at the MTOC

Compared to wild-type and p.Glu774Gly altered BICD2-EGFP, p.Ser107Leu altered BICD2-EGFP (green) shows increased localization at the MTOC (visualized with γ-tubulin, red). The graph and error bars represent the mean and SEM of mean EGFP intensity at the MTOC (white bars) and in the rest of the cell (black bars) measured in 34, 37, and 17 HeLa cells expressing wild-type, p.Ser107Leu, and p.Glu774Gly proteins, respectively. ∗p < 0.05. The scale bar represents 10 μm. The following abbreviations is used: NS, not significant.