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. 2013 Mar 6;34(22):1670–1680. doi: 10.1093/eurheartj/eht049

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© The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com.

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Association of effects of adding an oral anticoagulant to single (aspirin) or dual (aspirin and clopidogrel) antiplatelet therapy on rate of MACE with effects on rate of clinically significant bleeding events after an acute coronary syndrome. Random-effects meta-regression, stratified on number of antiplatelet drugs. The area of a circle representing a study arm is proportional to its weight in the random-effects model. Shaded areas are 95% confidence intervals. HR, hazard ratio; MACE, major adverse cardiovascular events; Riv, rivaroxaban; Dab, dabigatran, Api, apixaban; Dar, darexaban; Xim, ximelagatran; b.i.d., twice daily; o.d., once daily; number denotes strength in milligram.