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. Author manuscript; available in PMC: 2013 Jun 7.
Published in final edited form as: Adv Immunol. 2012;115:141–159. doi: 10.1016/B978-0-12-394299-9.00005-9

Figure 2. Effector mechanism of IL-3-elicited and TSLP-elicited basophils.

Figure 2

A, TSLP-elicited basophils are smaller and less granular than IL-3-elicited basophils and express elevated levels of IL-18Rα and IL-33R on their surface. TSLP-elicited basophils produce exaggerated amounts of IL-4, IL-6, CCL3, CCL4, CCL12 and Cxcl2 compared to IL-3-elicited basophils. B, IL-3-elicited basophils are larger and more granular than TSLP-elicited basophils and are potent producer of histamines, leukotrienes, CCL2 and CCL7 in response to IgE-mediated FcεRI crosslinking.