Figure 4.

Alignment of the amino acid sequences of selected RbpA orthologues. STRCO, S. coelicolor, NP_625703; FRASC, Frankia sp. CcI3, YP_481367; NOCFA, Nocardia farcinica, YP_119325; M. tuberculosis H37Rv, NP_216566. Residues that coordinate a zinc atom in RbpA^Sc, or form a stabilizing hydrogen bonding network in RbpA^Mt, are indicated with black dots. Arginine residues that when mutated prevent σ^HrdB interaction are indicated by grey dots (Figure 6). The β-strand secondary structure elements in the RCD domain are indicated, as are predicted α-helices in the C-terminal region.