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. 2013 Apr 16;288(23):16775–16787. doi: 10.1074/jbc.M113.467159

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — A, Binding of TRITC-tagged TMPM8 with the cell surface membrane of Cdr1p and TMH8 mutant variants (F1233A and P1238A) overexpressing in S. cerevisiae (AD1-8u⁻) cells. B, effect of TMPM8 on NR efflux in TMH8 mutant variants overexpressing in S. cerevisiae (AD1-8u⁻) cells in panels i and ii. C, helical wheel representation of the TMH8 of Cdr1p sequence from Met¹²²⁹ to Leu¹²⁴⁶. The seven essential variants (M1229A, V1232A, F1233A, F1235A, I1237A, V1243A, and Q1245A) are circled. D, three-dimensional views of helix of all seven mutant variants (M1229A, V1232A, F1233A, F1235A, I1237A, V1243A, and Q1245A). All seven mutant variants are labeled with their residues numbered and one-letter amino acid codes (red colors). The helical structure was made with the PyMOL program (40).