FIGURE 9.
A, in vivo efficacy of TMPM8 against AR Candida cells. B, the mean log10 cfu of C. albicans in the kidney of control (untreated) and treated groups: FLC (5 mg/kg), TMPM (0.38 mg), FLC (5 mg/kg) + TMPM (0.38 mg/kg). Statistical analysis was done using Student's t test, and results were considered significant when p vales were less than 0.05. C, panel i, hemolysis caused by TMPM3 and TMPM8. TMPMs (400 μm) were incubated with 0.4% RBC in PBS. The results are expressed as the percentage of hemolysis. Panel ii, mammalian-cell cytotoxicity (MTT assay) of TMPM3 and TMPM8 at 500 μm against HeLa cells. Test samples were incubated with cells for 24 h in RPMI1640. Conc., concentration.