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Signaling pathway downstream of SOCE involved in turning off SOCE in endothelial cells. PAR-1-induced ER store Ca2+ depletion via phospholipase C (PLC)-inositol 1,4,5-triphosphate (IP3) activates SOCE. SOCE signal activates CaMKKβ-AMPKα1-p38β MAPK signal axis, which in turn phosphorylates STIM1 to terminate SOCE in endothelial cells. DAG, diacylglycerol.
