Table 2.

Grade 3 Toxicities Occurring in > 5% of Patients and All Grade 4 Toxicities^*

Toxicity	Grade 3		Grade 4
	No.	%	No.	%
Hypertension	12	36	0	0
Hand-foot-skin reaction	8	24	0	0
Hypophosphatemia†	5	15	0	0
Rash	3	9	0	0
Fatigue	2	6	0	0
Diarrhea	2	6	0	0
Lipase elevation†	2	6	0	0
Hyperuricemia	0	0	2	6
Thrombotic event	0	0	1	3

^*At least possibly study drug related.

^†All elevations in lipase and decreases in phosphate were asymptomatic.