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Criteria for Regorafenib Dose Modifications
| Dose Reduction | Predefined Dose Level (mg PO once per day) |
|---|---|
| Dose level 0 (standard dose) | 160 |
| First reduction (dose level − 1) | 120 |
| Second reduction (dose level − 2) | 80 |
| Third reduction (dose level − 3) | 40 |
Abbreviation: PO, orally.
