Table A3.

Dose Adjustments in Response to Day 1 Counts in Cycle Two and Later Cycles

Neutrophil Count (/mm3)	Platelet Count (/mm3)	Timing	Dose for Current Cycle*
≥ 1,000	≥ 75,000	Treat on time	Adjust dose by nadir counts in previous cycle
< 1,000	< 75,000	Delay up to 4 weeks until ANC ≥ 1,000 and platelets ≥ 75,000/mm3†	Adjust dose by nadir counts in previous cycle

Abbreviation: ANC, absolute neutrophil count.

^*Dose reductions below dose level − 3 were not allowed; if dose reductions below dose level − 3 were required, study drug administration was discontinued.

^†If no recovery after a 4-week delay, study drug administration was discontinued.