Table A1.
Univariate and Multivariate Cox Regression Survival Analyses of TTR of Breast Cancer in Cohort I
| Cohort I* (TTR) Variable | No. | Multivariate Adjusted (Cox)† |
Unadjusted (Cox) |
||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Tumor grade | |||||||
| 1 | 47 | 1 | — | 1 | — | ||
| 2 | 76 | 2.01 | 0.77 to 5.25 | .156 | 2.24 | 0.89 to 5.67 | .087 |
| 3 | 60 | 2.05 | 0.73 to 5.77 | .174 | 3.41 | 1.32 to 8.84 | .012 |
| Tumor size, cm | |||||||
| < 2 | 88 | 1 | — | 1 | — | ||
| ≥ 2-< 5 | 87 | 2.13 | 1.04 to 4.35 | .038 | 2.41 | 1.25 to 4.65 | .009 |
| ≥ 5 | 8 | 2.54 | 0.67 to 9.57 | .169 | 3.20 | 0.90 to 11.34 | .072 |
| ER status* | |||||||
| Negative | 32 | 1 | — | ||||
| Positive | 151 | 0.83 | 0.40 to 1.73 | .622 | |||
| PR status | |||||||
| Negative | 64 | 1 | — | 1 | — | ||
| Positive | 119 | 0.36 | 0.18 to 0.72 | .004 | 0.35 | 0.18 to 0.69 | .002 |
| Nuc-pYStat5 | |||||||
| Low (0) | 105 | 2.49 | 1.23 to 5.05 | .012 | 2.35 | 1.18 to 4.67 | .015 |
| High (> 0) | 78 | 1 | — | 1 | — | ||
NOTE. Cohort I: n = 233; 183 (79%) evaluable; 45 (25%) of 183 events.
Abbreviations: TTR, time to recurrence; HR, hazard ratio; ER, estrogen receptor; PR, progesterone receptor; Nuc-pYStat5, nuclear localized and tyrosine phosphorylated Stat5.
*
Stratified by ER status, except for univariate (unadjusted) ER status which was done as Weibull.
†
Global test for Cox regression proportional hazards passed; Global test:χ2(4) = 3.84, P = .43.