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The role of the receptor activator of nuclear factor kappa B (RANK) and RANK ligand (RANKL) in normal bone physiology. RANK signaling is a central regulator of osteoclast differentiation, activity, and survival. Osteoblasts promote this by secreting RANKL. Osteoprotegerin (OPG) is a soluble decoy receptor for RANKL and serves as a negative regulator. GM-CFU, granulocyte-macrophage colony-forming unit. Adapted.14
