Fig. 3.
Overview of the projection of crizotinib minimum efficacious concentration (C eff) in patients based on the exposure-response relationships for ALK inhibition versus antitumor efficacy in nonclinical xenograft models. Concentration-response curves for crizotinib-mediated ALK inhibition and tumor growth inhibition (TGI) were simulated at the concentration range of 1 to 10,000 ng/mL with sigmoidal E max model using the pharmacodynamic parameters (EC 50, E max and γ) obtained from a mouse xenograft model with H3122 NSCLC cells