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Summary of Crizotinib Effective Concentration Estimates for Target Modulation and Antitumor Efficacy in Mouse Xenograft Models with H3122 NSCLC or GTL16 GC Cells
| Xenograft Model | PD Parameter | EC 50,vitro | EC 50,vivo | EC 90,vivo |
|---|---|---|---|---|
| nM free | nM free | nM free | ||
| H3122 NSCLC | ALK | 60 | 19 | – |
| TGI | – | 20 | – | |
| GTL16 GC | MET | 10 | 1.5 | 13 |
| TGI | – | 17 | – |
–, not calculated
