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Renal handling of cisplatin, carboplatin, oxaliplatin, and nedaplatin by OCT2 and MATE. Cisplatin is transported by OCT2 and, to a much lesser extent, by MATE. Cisplatin accumulates at higher levels than other platinum agents in the kidney, which causes nephrotoxicity. Carboplatin and nedaplatin are not transported by OCT or MATE. Oxaliplatin is a substrate for OCT2 and MATE but does not induce nephrotoxicity
