Table II.
Compound | Concentration (mM) | Relative transport rate (%) |
---|---|---|
Codeine | 10 | 71 ± 5*** |
Clonidine | 10 | 69 ± 5*** |
Diphenhydramine | 5 | 41 ± 6*** |
Diphenhydramine | 10 | 30 ± 2*** |
MDMA | 10 | 35 ± 7*** |
Naloxone | 3 | 74 ± 5*** |
N-methyl naloxone | 3 | 102 ± 8 |
Nicotine | 20 | 27 ± 1*** |
Oxycodone | 10 | 77 ± 5*** |
Tramadol | 10 | 39 ± 8*** |
Cis-inhibition of the BBB transport of [3H]-nicotine (8 nM) by an unlabeled compound was evaluated by in situ brain perfusion in Krebs carbonate perfusion fluid (pHe 7.40) for 60 s in Swiss mice. Brain transport (K in) for [3H]-nicotine (8 nM) in controls, set at 100%, was 18.1 ± 0.9 μl/s/g (100 ± 4%). Data represent the means ± SD (n = 4–7)
***p < 0.001 for the experimental group compared to the control group