Table II.

Effects of Drugs on [³H]-nicotine Transport at the Mouse BBB

Compound	Concentration (mM)	Relative transport rate (%)
Codeine	10	71 ± 5***
Clonidine	10	69 ± 5***
Diphenhydramine	5	41 ± 6***
Diphenhydramine	10	30 ± 2***
MDMA	10	35 ± 7***
Naloxone	3	74 ± 5***
N-methyl naloxone	3	102 ± 8
Nicotine	20	27 ± 1***
Oxycodone	10	77 ± 5***
Tramadol	10	39 ± 8***

Cis-inhibition of the BBB transport of [³H]-nicotine (8 nM) by an unlabeled compound was evaluated by in situ brain perfusion in Krebs carbonate perfusion fluid (pH_e 7.40) for 60 s in Swiss mice. Brain transport (K _in) for [³H]-nicotine (8 nM) in controls, set at 100%, was 18.1 ± 0.9 μl/s/g (100 ± 4%). Data represent the means ± SD (n = 4–7)

***p < 0.001 for the experimental group compared to the control group