Fig. 2.

Visual predictive check of the final model between 0 and 24 h after a single oral administration of 500 mg metformin. A total of 1,000 datasets were simulated using the final pharmacokinetic parameter estimates. Open circle, observed metformin serum concentrations; the 90% confidence interval of the simulated concentrations (gray area) and observed concentration (solid line) of the 5th, median, and 95th percentile