Table I.
Allele Frequencies of OCT1, OCT2, OCT3, OCTN1, MATE1, and MATE2-K Variants in Korean Population
| Gene | Nucleotide change (A > Ba) | Protein variation | n | Frequency (%) | ||||
|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | Korean | Asian (6,8,9,21,27,30–32) | European (8,21,27,32–34) | |||
| OCT1 | 289C > A | Q97K | 96 | 0 | 0 | 0 | 2 (JA) | |
| 350C > T | P117L | 96 | 0 | 0 | 0 | 2 (JA) | ||
| 616C > T | R206C | 96 | 0 | 0 | 0 | 1 (JA) | ||
| 1022C > T | P341L | 72 | 22 | 2 | 13.5 | 16.8 (JA) | 0 (EA) | |
| OCT2 | 596C > T | T199I | 96 | 0 | 0 | 0 | 0.9 (JA) | 0 (EC) |
| 602C > T | A201M | 95 | 1 | 0 | 0.5 | 1.3 (JA) | 0 (EC) | |
| 808 G > T | A270S | 81 | 15 | 0 | 7.8 | 16.8 (JA) | 16 (EA) | |
| OCT3 | 1199C > T | T400I | 96 | 0 | 0 | 0 | 0 (AS) | 0.5 (EA) |
| 1,267 G > T | V423F | 96 | 0 | 0 | 0 | 6.8 (JA) | 0 (CEU) | |
| OCTN1 | 917C > T | T306I | 10 | 52 | 34 | 62.5 | 64.2 (AS) | 33.8 (EA) |
| 1507C > T | L503F | 96 | 0 | 0 | 0 | 0 (AS) | 41.2 (EA) | |
| MATE1 | 191 G > A | G64D | 95 | 1 | 0 | 0.5 | 0.6 (JA) | |
| 373C > T | L125F | 95 | 1 | 0 | 0.5 | 0.7 (AS) | 0 (EA) | |
| 929C > T | A310V | 96 | 0 | 0 | 0 | 2.2 (JA) | ||
| 983A > C | D328A | 96 | 0 | 0 | 0 | 0.6 (JA) | ||
| 1421A > G | N474S | 96 | 0 | 0 | 0 | 0.6 (JA) | ||
| MATE2-K | 130 G > A | 30 | 44 | 22 | 45.8 | 48.5 (AS) | 26.2 (EA) | |
| 192 G > T | K64N | 96 | 0 | 0 | 0 | 0.6 (JA) | ||
| 632_633GC > TT | G211V | 96 | 0 | 0 | 0 | 1.7 (JA) | ||
AS Asian American; CEU Caucasians in Utah; EA European American; EC European Caucasian; JA Japanese Asian
aThe major (i.e., more frequent or active) alleles were designated A and the minor alleles B. A/A, A/B, and B/B represent individuals homozygous for the major allele, heterozygous for the minor allele, and homozygous for the minor allele, respectively. A/A denotes carriers of no inactive allele and B/B denotes carriers of two inactive alleles