Table II.
Pharmacokinetic Parameters of Metformin in Relation to OCT1-1022C > T, OCT2-808 G > T, OCTN1-917C > T, and MATE2-K-130 G > A Genotypes After a Single Oral Administration of 500 mg Metformin
| Gene/genotype | AUCinf (mg h L−1) | P | C max (mg/L) | P | |
|---|---|---|---|---|---|
| OCT1 | 1022CC (n = 72) | 5.14 ± 1.48 | 0.047 | 0.84 ± 0.24 | 0.124 |
| 1022CT/TT (n = 24) | 6.23 ± 2.06 | 0.97 ± 0.31 | |||
| OCT2 | 808GG (n = 81) | 5.14 ± 1.46 | 0.007 | 0.84 ± 0.25 | 0.012 |
| 808GT (n = 15) | 6.24 ± 1.07 | 0.98 ± 0.21 | |||
| OCTN1 | 917CC (n = 10) | 3.98 ± 1.21 | 0.021 | 0.63 ± 0.16 | 0.018 |
| 917CT/TT (n = 86) | 5.49 ± 1.64 | 0.88 ± 0.28 | |||
| MATE2-K | 130GG (n = 30) | 5.34 ± 1.80 | 0.565 | 0.91 ± 0.29 | 0.761 |
| 130GA/AA (n = 66) | 5.84 ± 1.41 | 0.93 ± 0.25 | |||
Data shown as mean value ± SD. P values by Mann–Whitney test between two genotypes
AUC inf area under the serum concentration–time curve from zero to time infinity, C max peak concentration