. 2013 Jan 15;15(2):415–426. doi: 10.1208/s12248-012-9431-9

Table IV.

Final Estimate of the FA of CYP2C19 for Various Genotypes with Respect to the Wild-Type (*1*1) Genotype

Genotype	Frequency^a (%)				Phenotype^a	FA^b	90% CI^c
Genotype	Caucasian	Asian	African American	Hispanic	Phenotype^a	FA^b	90% CI^c
22	3.2	8.4	5.2	2	PM	0.005	0.002–0.008
12	16.8	44.4	18.8	17.2	IM	0.30	0.25–0.36
217	3.2	3.6	9.2	4.4	Unknown	0.80	0.50–1.19
117	22.8	5.6	20.4	20.4	EM	1.59	1.24–1.85
1717	2.8	1.6	2.8	2.4	UM	2.03	1.28–2.62

FA fractional activity, CI confidence interval

^aFrequencies and phenotypes as reported by Martis et al. (15). The frequencies of the reference *1*1 genotype reported in the study from Martis et al. were 49.2%, 36.4%, 38.4%, and 50.4% in Caucasians, Asians, African Americans, and Hispanics, respectively

^bFA was calculated as the mean of the Bayesian posterior distribution

^cCI was calculated as the range between the 5th and the 95th percentiles of the Bayesian posterior distribution