Table V.
Initial Estimate of the IR for Various CYP2C19 Inhibitors
| Inhibitor | Daily dose (mg) | IR | Reference |
|---|---|---|---|
| Clopidogrel | 75a | 0.26 | (16) |
| Fluconazole | 400/200b | 0.76 | (69) |
| Fluoxetine | 60 | 0.44 | (70) |
| Fluvoxamine | 50 | 0.97 | (60) |
| Moclobemide | 300 | 0.62 | (61) |
| Omeprazole | 40 | 0.43 | (71) |
| Pantoprazole | 80 | 0.25 | (72) |
| Ticlopidine | 300 | 0.52 | (73) |
| Voriconazole | 800/400b | 0.66 | (69) |
IR inhibition ratio
aA single dose of 300 mg was administered on the first day and then a 75-mg dose was administered once daily for three consecutive days
bThe daily dose was halved on the second day of the study. Doses are given as first dose/second dose