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Published AUC Ratios Used for the External Validation Step
| Inhibitor | Substrate drug | Observed AUC ratio of substrate drug | Reference |
|---|---|---|---|
| Clopidogrel | Sibutramine | 2.27 | (74) |
| Fluconazole | Omeprazole | 6.29 | (18) |
| Fluvoxamine | Lansoprazole | 3.83 | (75) |
| Lansoprazole R | 8.99 | (17) | |
| Lansoprazole S | 13.97 | (17) | |
| Rabeprazole | 2.82 | (76) | |
| Diazepam | 2.80 | (77) | |
| Omeprazole | Moclobemide | 2.21 | (43) |
| Nelfinavir | 0.70 | (78) | |
| Diazepam | 1.64 | (79) | |
| Proguanil | 1.47 | (80) | |
| Clopidogrel | 1.51 | (72) | |
| Clopidogrel | 1.44 | (72) |
