Table VII.

Final Estimate of the IR of Various CYP2C19 Inhibitors

Inhibitor	Daily dose (mg)a	IRb	90% CIc
Fluvoxamine	50–150	0.98	0.95–0.99
Fluconazole	100–400	0.78	0.62–0.90
Voriconazole	400–800	0.64	0.43–0.82
Moclobemide	300	0.61	0.39–0.80
Ticlopidine	300	0.51	0.29–0.72
Fluoxetine	60	0.44	0.24–0.66
Omeprazole	40–80	0.43	0.24–0.64
Clopidogrel	75	0.28	0.13–0.48
Pantoprazole	80	0.26	0.12–0.45

IR inhibition ratio, CI confidence interval

^aRange of the daily dose used in published drug interaction studies

^bIR was calculated as the mean of the Bayesian posterior distribution

^cCI was calculated as the range between the 5th and the 95th percentiles of the Bayesian posterior distribution