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Pharmacokinetics of Griseofulvin (Griseofulvin HPMCAS 20/80) in Rats (n = 4) for Various Amorphous Solid Dispersions
| PK parameters/formulation | T max ± SD (h) | C max ± SD (uM) | AUC ± SD (uM × h) | CL/F ± SD (L/h/kg) |
|---|---|---|---|---|
| Physical mixture | 4.0 ± 0.0 | 3.2 ± 1.3 | 13.9 ± 5.2 | 17.1 ± 7.2 |
| Rapid evaporation (Evap ASD) | 4.0 ± 2.8 | 9.9 ± 4.9 | 50.4 ± 21.2 | 5.0 ± 2.6 |
| Lyophilization (Lyo ASD) | 1.2 ± 1.9 | 9.0 ± 3.1 | 31.9 ± 9.7 | 7.1 ± 2.0 |
| Spray-dried (SDD) | 0.2 ± 0.1 | 22.8 ± 8.1 | 46.2 ± 19.7 | 5.2 ± 2.1 |
