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. 2013 Apr 17;33(16):7027–7037. doi: 10.1523/JNEUROSCI.5924-12.2013

Figure 4.

Figure 4.

Cerebral Aβ protein load was significantly reduced in immunized APPswe/PS1ΔE9 Tg mice. A–F, Representative staining is shown for R1282-positive plaques in HC, frontal CTX, and CB in vehicle-treated APPswe/PS1ΔE9 Tg mice (A–C) and MER5101-vaccinated Tg mice (D–F). G, Quantitative image analysis demonstrated a significant reduction in R1282-positive Aβ plaque burden after MER5101 vaccination. H–M, Representative staining is shown for Thio S-positive fibrillar plaques in HC, frontal CTX, and CB in both vehicle-treated Tg (H–J) and MER5101-vaccinated Tg mice (K–M). N, Quantitative image analysis revealed that cerebral Thio S-positive plaques were significantly decreased in MER5101-vaccinated APPswe/PS1ΔE9 Tg mice versus vehicle-treated Tg controls. O–Q, The levels of Aβx-40 (O), Aβx-42 (P), and Aβ1-total (Q) in TBS-soluble and guanidine-soluble (TBS-insoluble) fractions of brain homogenates and plasma were measured by Aβ ELISA. Data are represented as mean ± SEM. *p < 0.05; **p < 0.01.