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. 2013 Apr 17;33(16):7027–7037. doi: 10.1523/JNEUROSCI.5924-12.2013

Figure 6.

Figure 6.

Enhanced synaptic IR and reduced neuritic plaques were observed in the HC of MER5101-vaccinated APPswe/PS1ΔE9 Tg mice compared with vehicle Tg controls. The synaptic density was evaluated by staining with a presynaptic marker, SYP (A, B), and a postsynaptic marker, PSD-95 (E, F). Both SYP and PSD-95 immunoreactivities were increased in vaccinated APPswe/PS1ΔE9 Tg mice (B, F) compared with vehicle Tg controls (A, E). The optical density of SYP (C, D) and PSD-95 (G, H) IR was quantified in both the CA1 and CA3 regions of mouse HC for all treatment groups. Vehicle-treated APPswe/PS1ΔE9 Tg mice had significantly less SYP- and PSD-95-positive synaptic staining in HC compared with Wt mice. However, MER5101 vaccination restored synaptic staining close to Wt levels. Neuritic plaques, labeled by anti-human APP mAb, 22C11, were decreased in the HC of vaccinated APPswe/PS1ΔE9 Tg mice compared with vehicle controls. *p < 0.05; **p < 0.01.