Table I. Changed prohormone-derived peptides and unchanged known neuropeptides in rat dorsal striatum (DS).

The identification list of neuropeptides in the DS. The peptides include known neuropeptides, changed peptides, and putative neuropeptides identified using the dual LC-FT-MS/MS approach. PTMS means Δ mass −17.03, pyro-glutamate formation from glutamic acid or glutamine; Δ mass −0.98, amidation. * indicates significantly changed peptides due to chronic nicotine treatment. The sequence of dynorphin A is confirmed using de novo sequencing. § indicates the peptides identified using targeted LC-FT-MS/MS, and # means the peptides identified using directed LC-FT-MS.