Table II. List of potential novel lysosomal transporters.
Candidates with two TM or more, of unknown function or with an attributed transport function, are shown. The localizations are as follows: ER, endoplasmic reticulum, Golgi; EL, endo-lysosomes; Misc, miscellaneous; PM, plasma membrane; U, unknown. The functions are as follows: T, transporters, channels, and ion pumps; U, unknown; TM, number of transmembrane domains; SpI, spectral index; NA, not applicable (proteins identified in MbL+ exclusively). The lysosomal localization of MFSD1 has been shown during the course of this (66).
| Gene name | Description | Accession no. | TM | Localization | Function | SpI | No. of peptides | Coverage |
|---|---|---|---|---|---|---|---|---|
| Abca6 | Abca6, similar to ATP-binding cassette, subfamily A (ABC1), member 6 | IPI00762951 | 13 | U | T | 0.76 | 6 | 4.61 |
| Abca8a | Abca8a, similar to ATP-binding cassette, subfamily A (ABC1), member 8a | IPI00763783 | 11 | PM | T | NA | 4 | 1.18 |
| Abcb11 | Abcb11, bile salt export pump | IPI00195615 | 9 | PM | T | 0.90 | 15 | 14.76 |
| Abcc10 | Abcc10, ATP-binding cassette, subfamily C (CFTR/MRP), member 10 | IPI00371742 | 14 | PM | T | 0.84 | 15 | 10.85 |
| Abcc2 | Abcc2, canalicular multispecific organic anion transporter 1 | IPI00205806 | 14 | PM | T | 0.94 | 28 | 24.08 |
| Abcc6 | Abcc6, multidrug resistance-associated protein 6 | IPI00207513 | 12 | PM | T | 0.97 | 17 | 17.58 |
| Ank | Ank, progressive ankylosis protein homolog | IPI00765376 | 8 | PM | T | NA | 2 | 6.63 |
| Atp11c-ps1 | 128-kDa protein | IPI00370178 | 8 | U | T | 0.63 | 25 | 27.32 |
| Atp2b1 | Atp2b1, isoform D of plasma membrane calcium-transporting ATPase 1 | IPI00231268 | 7 | PM | T | NA | 5 | 4.26 |
| Atp8a1 | Atp8a1, similar to ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | IPI00952342 | 8 | PM | T | NA | 10 | 9.08 |
| C7orf23 | RGD1562351, hypothetical protein LOC499990 | IPI00565669 | 3 | MPN | U | 0.60 | 4 | 23.73 |
| C9orf91 | RGD1304595, hypothetical protein LOC298104 | IPI00357901 | 2 | U | U | NA | 7 | 22.51 |
| Cacfd1 | RGD1311501, hypothetical protein LOC296599 | IPI00363948 | 3 | U | T | NA | 2 | 14.62 |
| Gjb1 | Gjb1, Gap junction β-1 protein | IPI00207191 | 4 | PM | T | NA | 4 | 15.19 |
| Mfsd1 | Mfsd1, similar to major facilitator superfamily domain containing 1 | IPI00373212 | 11 | U | T | NA | 6 | 18.75 |
| Myadm | Myadm, myeloid-associated differentiation marker | IPI00339007 | 8 | U | U | 0.76 | 2 | 8.49 |
| P2rx4 | P2rx4, P2X purinoceptor 4 | IPI00324987 | 2 | PM | T | 0.87 | 13 | 38.4 |
| Sidt2 | Sidt2, SID1 transmembrane family, member 2 | IPI00369576 | 9 | EL | U | 0.82 | 4 | 6.23 |
| Slc12a9 | Slc12a9, solute carrier family 12 member 9 | IPI00198772 | 11 | PM | T | NA | 6 | 9.85 |
| Slc22a1 | Slc22a1, isoform 1 of solute carrier family 22 member 1 | IPI00213324 | 10 | PM | T | 0.77 | 6 | 15.81 |
| Slc22a7 | Slc22a7, solute carrier family 22 member 7 | IPI00203971 | 11 | PM | T | 0.83 | 12 | 25.23 |
| Slc24a6 | Slc24a6, sodium/potassium/calcium exchanger 6 | IPI00464527 | 12 | PM | T | 0.92 | 5 | 12.27 |
| Slc26a1 | Slc26a1, sulfate anion transporter 1 | IPI00207298 | 9 | PM | T | 0.74 | 10 | 25.6 |
| Slc31a1 | Slc31a1, high affinity copper uptake protein 1 | IPI00231403 | 3 | PM | T | 0.79 | 5 | 16.58 |
| Slc37a2 | Slc37a2, similar to solute carrier family 37 (glycerol 3-phosphate transporter), member 2 | IPI00569704 | 12 | ER | T | 0.98 | 5 | 16.4 |
| Slc38a4 | Slc38a4, sodium-coupled neutral amino acid transporter 4 | IPI00189469 | 11 | PM | T | 0.95 | 7 | 14.63 |
| Slc38a7 | Slc38a7, putative sodium-coupled neutral amino acid transporter 7 | IPI00421684 | 11 | U | T | NA | 7 | 10.8 |
| Slc39a1 | Slc39a1, similar to zinc transporter ZIP1 | IPI00373235 | 6 | PM | T | 0.96 | 6 | 19.75 |
| Slc40a1 | Slc40a1, solute carrier family 40 member 1 | IPI00326002 | 10 | PM | T | NA | 2 | 5.61 |
| Slc46a3 | Slc46a3, solute carrier family 46 member 3 | IPI00364398 | 11 | U | T | NA | 2 | 5.86 |
| Slc4a1 | Slc4a1, solute carrier family 4, member 1 | IPI00231379 | 10 | PM | T | NA | 6 | 8.41 |
| Slc7a2 | Slc7a2, cationic amino acid transporter-2 | IPI00608159 | 16 | PM | T | 0.92 | 9 | 14.63 |
| Slc7a2 | Slc7a2, cationic amino acid transporter-2A | IPI00206144 | 14 | PM | T | 0.95 | 6 | 8.98 |
| Slco1b2 | Slco1b2, isoform 1 of solute carrier organic anion transporter family member 1B2 | IPI00215390 | 11 | PM | T | 0.73 | 14 | 27.91 |
| Slco2a1 | Slco2a1, solute carrier organic anion transporter family member 2A1 | IPI00231272 | 11 | PM | T | 0.76 | 3 | 5.13 |
| Slco2b1 | Slco2b1, solute carrier organic anion transporter family member 2B1 | IPI00230858 | 12 | U | T | 0.75 | 3 | 5.56 |
| Syngr2 | Syngr2, synaptogyrin 2 | IPI00200093 | 4 | PM | U | 0.72 | 2 | 4.7 |
| Sypl1 | Sypl, synaptophysin-like protein | IPI00471762 | 3 | Misc | U | 0.95 | 4 | 20.16 |
| Tmem104 | Tmem104 similar to CG5262-PA | IPI00778760 | 11 | U | T | NA | 6 | 11.29 |
| Tmem144 | Tmem144, transmembrane protein 144 | IPI00373219 | 10 | U | U | 0.95 | 5 | 23.85 |
| Tmem175 | Tmem175, transmembrane protein 175 | IPI00211068 | 9 | U | U | NA | 5 | 18.44 |
| Tmem192 | Tmem192, transmembrane protein 192 | IPI00364640 | 4 | EL | U | NA | 4 | 12.78 |
| Tmem50b | Tmem50b, transmembrane protein 50B | IPI00373040 | 4 | ER | U | NA | 2 | 12.03 |
| Tmem63a | Tmem63a, similar to transmembrane protein 63a | IPI00363369 | 11 | EL | U | NA | 4 | 5.1 |
| Ttyh2 | Ttyh2, similar to tweety 2 | IPI00763162 | 6 | PM | T | NA | 5 | 4.81 |
| Ttyh3 | Ttyh3, tweety homolog 3 | IPI00363776 | 5 | PM | T | NA | 4 | 7.44 |
| UST4r | UST4r, putative integral membrane transport protein | IPI00202688 | 7 | U | T | 0.89 | 6 | 10.33 |