TABLE 2.
Time Course of Hematologic and Biochemical Parameters in Probands Under Oral Iron Supplementation
| Date | Tx duration, mo | Patient age, y | OEI suppl | Hb, g/L | MCV, fL | RDW, % | Retic, 10^9/L | Iron, µmol/L | Ferritin, µg/L | Transf, g/L | Transf saturation |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 9/16/1999 | — | 3 | 6 mg/kg/d | 75 | 64.1 | 16.9 | 0.024 | <1 | 348 | 2.00 | 0.02 |
| 1/19/2000 | 4 | 3 | ↑ up to 10mg/kg/d | 100 | 64 | 16.4 | 0.050 | 3,0 | 217 | 2.24 | 0.05 |
| 10/14/2000 | 12 | 4 | Stop Tx | 112 | 71.9 | 14.9 | ND | ND | ND | ND | ND |
| 11/22/2000 | — | 4 | Restart at 12 mg/kg/d | 104 | 72.8 | 14.6 | ND | ND | 325 | ND | ND |
| 9/12/2001 | 9 | 5 | Stop Tx | 112 | 80.3 | 12.9 | ND | ND | ND | ND | ND |
| 5/3/2002 | — | 5 | Restart at 10 mg/kg/d | 101 | 73.4 | 13.6 | ND | 2.0 | 291 | 1.73 | 0.05 |
| 6/12/2002 | 1 | 6 | ↓ down to 6 mg/kg/d | 107 | 73.3 | 15.1 | 0.068 | 3.0 | 379 | 2.16 | 0.05 |
| 9/6/2002 | 4 | 6 | Stop Tx | 113 | 75.5 | 13.8 | ND | ND | ND | ND | ND |
| 3/28/2003 | — | 6 | Restart at 9 mg/kg/d | 102 | 69.5 | 16.4 | ND | 4.0 | 376 | ND | ND |
| 11/3/2003 | 7 | 7 | Stop Tx | 114 | 75.7 | 14.6 | 0.066 | 4.0 | 654 | 2.12 | 0.07 |
| 5/11/2004 | — | 7 | No Tx | 109 | 81.6 | 14.5 | ND | 2.0 | 467 | 2.14 | ND |
| 10/18/2004 | — | 8 | Restart at 4 mg/kg/d | 106 | 73.6 | 15.3 | 0.057 | 2.0 | 391 | 2.06 | 0.04 |
| 3/17/2006 | 16 | 9 | Stop Tx | 119 | 78 | 14.3 | ND | ND | ND | ND | ND |
| 8/18/2006 | — | 10 | Restart at 6 mg/kg/d | 103 | 74.9 | 15.5 | ND | 3.1 | 439 | 2.07 | 0.06 |
| 10/26/2007 | 14 | 11 | ↓ down to 1.2 mg/kg/d | 119 | 76.1 | 14.6 | ND | 5.0 | 598 | ND | ND |
| 5/23/2008 | 21 | 12 | ↓ down to 1.1 mg/kg/d | 113 | 73.1 | 15.6 | 0.057 | 4.1 | 390 | ND | ND |
| 11/20/2009 | 39 | 13 | ↓ down to 0.7 mg/kg/d | 119 | 72.2 | 17.2 | ND | ND | 512 | ND | ND |
| 12/17/2010 | 51 | 14 | ↓ down to 0.5 mg/kg/d | 109 | 67.2 | 18.9 | 0.038 | 3.2 | 168 | 2.24 | 0.06 |
| 12/20/2011 | 64 | 15 | 0.5 mg/kg/d | 115 | 66.8 | 19.1 | ND | 2.6 | ND | ND | ND |
ND, not determined; OEI suppl, oral elemental iron supplementation; RDW, red cell distribution width; Retic, reticulocytes; Transf, transferrin; Tx, treatment; ↑, increase; ↓, decrease.