Table 2.
Baseline clinical characteristics of WRN and no-WRN patients according to CKD or no-CKD status
| No CKD (n3096=3096) |
CKD (n=910) |
||||||
|---|---|---|---|---|---|---|---|
| Variable | Level | WRN: ΔSC ≥0.3, n=516 (%) |
No WRN: ΔSC<0.3, n=2580 (%) |
P-value | WRN: ΔSC ≥0.3, n=305 (%) |
No WRN: ΔSC<0.3, n=605 (%) |
P-value |
| Age at INR spike | Mean±s.d. | 61.9±14.8 | 60.9±15.7 | 0.1837 | 66.5±14.0 | 54.9±14.9 | 0.1093 |
| Gender | Female | 236 (46) | 1280 (50) | 0.1079 | 120 (39) | 254 (42) | 0.4450 |
| Male | 280 (54) | 1300 (50) | 185 (61) | 351 (58) | |||
| Racea | White | 412 (81) | 2093 (82) | 0.0947 | 213 (71) | 410 (68) | 0.6550 |
| Black | 87 (17) | 420 (16) | 86 (29) | 187 (31) | |||
| Asian | 0 (0) | 16 (1) | 0 (0) | 1 (0) | |||
| Native American | 0 (0) | 4 (0) | 0 (0) | 0 (0) | |||
| Other | 8 (2) | 18 (1) | 0 (0) | 1 (0) | |||
| Diabetes | No | 305 (59) | 1757 (68) | <0.0001 | 128 (42) | 247 (41) | 0.7414 |
| Yes | 211 (41) | 823 (32) | 177 (58) | 358 (59) | |||
| Diabetic | No | 495 (96) | 2551 (99) | <0.0001 | 246 (81) | 503 (83) | 0.3538 |
| nephropathy | Yes | 21 (4) | 29 (1) | 59 (19) | 102 (17) | ||
| Hypertension | No | 126 (24) | 827 (32) | 0.0006 | 27 (9) | 53 (9) | 0.9630 |
| Yes | 390 (76) | 1753 (68) | 278 (91) | 552 (91) | |||
| Heart failure | No | 257 (50) | 1647 (64) | <0.0001 | 58 (19) | 201 (33) | <0.0001 |
| Yes | 259 (50) | 933 (36) | 247 (81) | 404 (67) | |||
| Glomerular nephritis | No | 502 (97) | 2558 (99) | 0.0003 | 284 (93) | 576 (95) | 0.1911 |
| Yes | 14 (3) | 22 (1) | 21 (7) | 29 (5) | |||
| Nephrotic syndrome | No | 511 (99) | 2570 (100) | 0.0825 | 290 (95) | 589 (97) | 0.0743 |
| Yes | 5 (1) | 10 (0) | 15 (5) | 16 (3) | |||
| Polycystic kidneys | No | 504 (98) | 2535 (98) | 0.3698 | 291 (95) | 574 (95) | 0.7259 |
| Yes | 12 (2) | 45 (2) | 14 (5) | 31 (5) | |||
Abbreviations: CKD, chronic kidney disease; INR, international normalized ratio; SC, serum creatinine; WRN, warfarin-related nephropathy.
a
Data is not available for 50 patients.