Table 4.
Comparison of the photokilling efficiencies with the use of three groups of photosensitizersa
| PS group | Photosensitizer(s) | Photosensitizer concn | Log10 reduction in survival | Wavelength(s) (nm), light source | Light dose (J/cm2) | Reference |
|---|---|---|---|---|---|---|
| Phthalocyanine-based PS | ZnPcM, ZnPcS | 6 μM | 4–7 | 675, laser | 12–60 | 32 |
| BAM-SiPc | 0.0025–0.08 μM | 0.9 | 675, laser | 12 | 33 | |
| GaPcs | 3 μM | 4–5 | 635, LED | 50 | 34 | |
| Pc4 | 1 μM | 4–5 | 670–675, LED | 2 | 35 | |
| SiPc1, GePc1 | 1.8 μM | Eradication | 635, LED | 50 | 36 | |
| Porphyrin-based PS | Photofrin | 1 μg/ml | 400–700, Hg lamp | 9 | 37 | |
| PEI-ce6 | 1–10 μM | 4–6 | 665, laser | 16 | 38 | |
| TFAP(3+), TMAP(4+), TPPS(4−) | 1–5 μM | 5 | 300–800 | 162 | 39 | |
| Photofrin | 25 μg/ml | 630, laser | 45–135 | 40 | ||
| TMpyP | 5 μM | 5 | 300–800 | 162 | 41 | |
| Photogem | 50 μg/ml | 1.79–3.99 | 37.5 | 42 | ||
| SSO-P | Visible | 300 | 43 | |||
| Phenothiazine-based PS | TBO | 50 μM | 7 | 620–650, noncoherent | 10–20 | 20 |
| MB | 0.027 μM | 0.9 | 683, laser | 28 | 44 | |
| TBO, MB, MG | 320, 310, 270 μM | 3, 3, 2.5 | 660, laser | 39.5 | 45 | |
| TBO, MB, NMB | 20 μM | 0, 0, 4.43 | 635, 660, noncoherent | 10 | 9 | |
| TBO, MB | 320, 310 μM | 685 | 53 | 46 | ||
| Imidazoacridinone | C1330 | 100 μM | 6 | 385–480, noncoherent | 100 | This work |
ZnPcM, tetrakis-(3-methylpyridyloxy)phthalocyanine zinc(II); ZnPcS, tetrakis-(4-sulfophenoxy)phthalocyanine zinc(II); BAM-SiPc, silicon(IV) phthalocyanine; GaPcs, gallium(III) phthalocyanine; PEI-ce6, polyethyleneimine and chlorin(e6) conjugate; TFAP(3+), 5-(4-trifluorophenyl)-10,15,20-tris(4-trimethylammoniumphenyl)porphyrin iodide; TMAP(4+), 5,10,15,20-tetra(4-N,N,N-trimethylammonium phenyl)porphyrin p-tosylate; TPPS(4−), 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin; TMpyP, 5,10,15,20-tetra(4-N-methylpyridyl)porphyrin; SSO-P, 5-(4-carboxyphenyl)-10,15,20-tris(4-methylphenyl)porphyrin conjugated with polysilsesquioxane; MG, malachite green; NMB, new methylene blue.