Fig 1.
CD137-deficient mice are resistant to infection with G− bacteria but susceptible to infection with G+ bacteria. BALB/c CD137−/− and CD137+/+ littermates were inoculated i.p. with either G+ bacteria (5 × 108 S. aureus, 5 × 103 S. pneumoniae, or 8 × 107 E. faecalis organisms) (A) or G− bacteria (1 × 107 E. coli, 6 × 108 P. aeruginosa, or 2 × 106 S. Typhimurium organisms) (B), and mouse survival was monitored for 7 days. Each group contained 10 to 15 mice, and the results of 2 or 3 different experiments were pooled. *, P < 0.05; **, P < 0.01 (comparison with CD137+/+ mice, as determined by a log rank test).