Fig 7.

Microbial burden and cytokine levels in the target organs during coinfection are decreased by indomethacin administration. Mice were singly or dually infected; control mice were injected with sterile saline only. All mice received indomethacin at a dose of 5 mg/kg or vehicle 4 h prior to and 8 h after infection and sacrificed at 1 day postinoculation. (A and B) Quantitative counts of C. albicans and S. aureus in kidneys (A) and spleens (B) during infection; (C and D) cytokine levels in the kidneys (C) and spleens (D) of coinfected mice treated with indomethacin or vehicle. Infection groups were compared by the Mann-Whitney U test. *, P < 0.05. Horizontal bars and values were plotted as the medians; error bars represent interquartile ranges.