Fig 1.

Comparison of the GAS SF370 and M1T1 genomes. The linear diagrams show pairwise comparisons between the draft genome sequence of GAS M1T1 strain 5448 (top) and the complete genome sequences of the GAS M1T1 reference strain MGAS5005 (RefSeq accession no. NC_007297) and GAS M1 strain SF370 (RefSeq accession no. NC_002737). In each genome, prophages are shown as red (M1T1) or green (M1) boxes. Insertion sequences and ribosomal operons in MGAS5005 are shown as orange triangles and black boxes, respectively. The M12-derived 36-kb recombination region is indicated by gray boxes labeled M12. The colored blocks between each genome represent regions of conserved syntenic gene content, ranging in pairwise nucleotide identity (according to BLASTn) from 100% (dark blue) to 99% (yellow). The diagrams were prepared using the Easyfig genome comparison visualization tool (25).