Fig 3.

Kinetic analysis of Y. pestis bacterial burden in mice treated prophylactically with CpG ODN. CFU data for lung (A) and liver (B) tissue of wild-type C57BL/6 mice treated with 50 μg CpG ODN 1 day prior to intranasal infection with 20 MLD Y. pestis KIM D27. Control mice were left untreated or were treated with PBS. The data were pooled from 3 independent experiments and expressed as the medians and interquartile ranges (n = 9 to 15 mice per group per time point). ***, P value below 0.001; **, P value between 0.01 and 0.001; *, P value between 0.05 and 0.01. The dashed line indicates the limit of detection.