Fig 4.

CpG ODN-induced protection against Y. pestis infection is not dependent on adaptive immunity. Mice were treated intranasally with 50 μg CpG ODN 1 day prior to infection with 20 MLD Y. pestis KIM D27. Control mice were left untreated or were treated with PBS diluent. (A) Survival of B-cell-deficient μMT mice. The data were pooled from 2 independent experiments (n = 9 to 10 mice per group). (B) Survival of TCRbd-deficient mice. The data were pooled from 2 independent experiments (n = 10 mice per group). (C) Survival of RAG2-deficient mice. The data were pooled from 2 independent experiments (n = 11 to 12 mice per group).