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Susceptibility of IL-10+/+ and IL-10−/− mice to cutaneous LVS infection after neutralization of IL-17. C57BL/6 IL-10+/+ mice were inoculated i.d. with 5.0 × 104 CFU of LVS/mouse, while C57BL/6 IL-10−/− mice were inoculated i.d. with 4 × 106 CFU of LVS/mouse. The mice were also injected i.p. with 50 μg of rat IgG or neutralizing anti-IL-17 MAb on days 0, 1, 3, and 5 after bacterial challenge. Survival was monitored daily (eight mice/group). ***, P < 0.001; NS, not significant.
