Table 3.
Contents of novel reconstructed TF regulons in B. subtilis
| TF regulona | Target operon(s) | Functional roleb |
|---|---|---|
| BglR (YydK) | yyzE-bglA, bglR | C |
| BglZ (YkvZ) | bglC, bglZ | C |
| FruR | fruRKA | C |
| GamR (YbgA) | gamAP, gamR | C |
| GlcR | glcR-ywpJ | U |
| HisR (YerC) | hisZGDBHAFI, yuiF | A |
| IolR1 (DegA) | iolX, yrbE | C |
| LytT | lrgAB | R |
| MdxR (YvdE) | mdxD, mdxEFG-malAKL-pgcM | C |
| MsmR | msmREFG-melA | C |
| MurR (YbbH) | murQR-ybbF-amiE-nagZ-ybbC | C |
| NrdR | nrdIEF-ymaB | N |
| RbsR | rbsRKDACB | C |
| RhaR (YulB) | rhaEWRBMA | C |
| RhgR (YesS) | yesOPQ-urhG-rhgR-yesTUVWXYZ | C |
| RmgR (YtdP) | ytePRSTU | C |
| YbzH | ybcL, ybzH | R |
| YcxD | ycxC, ycxD | R |
| YczG | ycnE-nfrA2, yczG | R |
| YdfD-YisV | yisV, ydfD, yisU, ydfC | R |
| YdfF | ydfE, ydfF | U |
| YdfL | ydfK | R |
| YhcF | yhcEFGHI | R |
| YhdI-YdeL | yhdJ, yhdI, ydeK, ydeL | U |
| YhgD | yhgDE | U |
| YisR | yisQ | R |
| YizB | yizB-yitQR | U |
| YrkD | yrkD, yrkEFHIJ | R |
| YtcD | ytbDE, ytcD | U |
| YuaC | gbsAB | R |
| YvbF-YvaV | opuB(ABCD), yvbF, opuC(ABCD), yvaV | R |
| YvfU | yvfRSTU | U |
| YwbI | cidA-ywbG, ywbI | R |
| YwrC | ywrCBA | R |
| YybA | yybA, paiAB, yyaTS | R |
| YybR-YdeP | ydeP, yybR, ydeQ, ppaC, yfkO | R |
a
For novel regulators that were tentatively named in this work for the first time, the original TF name is given in parentheses.
b
Functional roles of target genes: A, amino acid metabolism; C, carbon metabolism; T, metabolite transport; N, nucleotide metabolism; O, cofactor metabolism; R, stress responses and drug resistance; U, unknown.