Table 4.
Content of B. subtilis regulons controlled by RNA elements
| RNA regulona | Target operon(s)b | Functional rolec |
|---|---|---|
| Cobalamin (B12 element) | btuFC-cbiZ-pduO | O |
| FMN (RFN element) | ribDEBAH, ribU | O |
| TPP (THI element) | thiC, thiT, ylmB, tenAI-thiOSGFD, ykoFEDC | O |
| Glycine | gcvTP1P2 | A |
| Lysine (L box) | yvsH, lysC | A |
| SAM (S box) | cysHP-sat-cysCG-sirBC, metK, metE3, metE2, metNPQ, metIC, metF, metE, mtnWXBD, mtnKA, yoaDCB | A |
| T box (various amino acid specificities) | alaS, hisS-aspS, cysES, glyQS, ileS, leuS, ilvBHC-leuABCD, yvbW, pheST, proI, proAB, serS, thrZS, trpS, rtpA-ycbK, tyrSZ, valS | A |
| PreQ1 | queCDEF | N |
| Purine (G box) | pbuG, purEKBCSQLFMNHD, pbuE, nupG, xpt-pbuX | N |
| PyrR | pyrBC-carAB-pyrKDFE, pyrP, pyrR | N |
| Ribosomal leaders | rplJL, rplM-rpsI, rplS, infC-rpmI-rplT, rplU-ysxB-rpmA | D |
| glmS | glmS | C |
| ykoK (M box) | mgtE | M |
| ykkC-yxkD | ykkCD, yxkD | R |
| ydaO | ktrAB, ydaO | U |
| ylbH | ylbH-coaD | U |
| yybP-ykoY | ykoY, yybP | U |
a
Regulons that operate by known metabolite-sensing riboswitches and aminoacyl-tRNA-sensing T boxes are underlined.
b
Novel predicted targets of known riboswitch regulons are underlined.
c
Functional roles of target genes: A, amino acid metabolism; R, stress response; C, amino sugar metabolism; M, metal homeostasis; N, nucleic base metabolism; O, cofactor metabolism; D, ribosomal proteins; U, unknown.