Fig 5.

A DNA-binding model for pUL15C. A model of 25-bp dsDNA docked onto the pUL15C structure. The docking was performed by superimposing the pUL15C structure onto that (PDB code 2QKB) of the RNase H1 in complex with a DNA-RNA hybrid, which was replaced with dsDNA. The loops L1 and L4 and the hairpin 620 to 633 are indicated. The active-site residues are shown as stick models for side chains and are labeled with D509, E581, D706, and D707. The positively charged residues that potentially interact with DNA are shown as blue stick models for side chains and are labeled.