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. 2013 Jun;87(12):6769–6781. doi: 10.1128/JVI.02445-12

Fig 7.

Fig 7

Increased cytokine production in response to TLR7/8 ligand is associated with spontaneous resolution and protection from infection. Intracellular expression of cytokines was studied in patients with HCV chronic evolution, patients with HCV spontaneous resolution, healthy donors, and HCV-negative IDUs. Baseline expression was subtracted from expression in the presence of TLR ligands. (A to C) Frequency of changes in total IL-6+ (A), IL-12+ (B), and TNF-α+ (C) ssRNA-stimulated mDCs. (D) Frequency of change in IL-6+, IL-12+, and TNF-α+ mDCs in response to ssRNA stimulation. The mean is represented by a horizontal bar. *, P < 0.05; **, P < 0.01; ***, P < 0.001. P values were determined by two-way ANOVA (repeated measures) or one-way ANOVA (comparison with healthy donors and HCV-negative IDUs).